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KMID : 0882420120830050619
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Korean Journal of Medicine
2012 Volume.83 No. 5 p.619 ~ p.623
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A Case of Acute Hepatitis B by Occult HBV Infection without HbsAg Seroconversion
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Jung Hye-Mi
Jun Dae-Won
Min Ji-Yeoun
Doo Eun-Young
Nam Kil-Woo
Kwon Young-Il
Kwon Oh-Wan
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Abstract
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Many studies have recently reported reactivation in hepatitis B surface antigen (HBsAg)-negative subjects with the use of biologic agents such as rituximab. However, occult hepatitis B virus infection itself has little clinical impact. We experienced a case of acute exacerbation caused by occult hepatitis B infection without HBsAg seroconversion. No mutation was found on the major hydrophilic loop of the S protein. The patient recovered from acute exacerbation after antiviral therapy. In conclusion, acute exacerbation can be induced by occult hepatitis B virus infection itself without reactivation. In such a case, antiviral therapy should be considered.
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KEYWORD
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Hepatitis B Surface Antigens, Hepatitis B, Rituximab
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